Searchable abstracts of presentations at key conferences in endocrinology

ea0038p229 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Anti-inflammatory effects of metformin and their relationship to the therapeutic action of the drug

Cameron Amy , Forteath Calum , Beall Craig , Rena Graham

Improvements in circulating cytokine levels have occurred in patients with endometriosis and chronic heart disease when prescribed the type 2 diabetes (T2D) drug metformin. However it is unclear how metformin exerts these effects and whether or not they are related to antihyperglycaemic effects in T2D. The purpose of this study is to investigate the relationship between anti-inflammatory and anti-hyperglycaemic effects of metformin in the liver, the main target tissue of the d...